YOU HAVE FOUND A NEW DRUG.HOW TO MOVE ABOUT NOW. DOSE AND DURATION OF TREATMENT FOR THE NEW DRUG.

FIRST SELECT THE BEST ANIMAL MODEL FOR THE DISEASE  IN WHICH YOU HAVE DECIDED TO WORK.

YOU HAVE A NEW DRUG IN YOUR HAND AND IS CONFUSED WHAT IS THE DOSE IN WHICH THE DESIRED EFFECT WILL COME

Lowest dose which show maximum protection or effect is the rule

How to find the best dose/standardization of doses for a new drug in an animal model??

You take multiple criteria for evaluating the disease progress or severity  and then administer the different  probable doses among which you are confused . Your aim is to find what will be your best suitable dose which will have a significant effect in decreasing the disease severity or produce maximum protection effect. 

The thing to note is that you will have the data of effect of the different doses on the same parameter which you wish to check.

This dose at which maximum benefit is seen is the best dose to give for the indication we intend to give.

How to find the duration of the treatment for a new drug in an animal model???

In the dose selected above now your aim is to find the duration of the therapy.You give treatment and then analyze the model at different time interval to find the best time duration in which the drug maximum effect has been obtained. The thing to  note is if you administer the drug more than this time ,some may argue that there will be no detrimental effect. Yes, of course but administering more than this time wont add to any beneficial effect too.